GW 3965 HYDROCHLORIDE
- Product Name
- GW 3965 HYDROCHLORIDE
- CAS No.
- 405911-17-3
- Chemical Name
- GW 3965 HYDROCHLORIDE
- Synonyms
- CS-742;GW3965 HCl;GW3965 HCl Salt;W 3965 HYDROCHLORIDE;GW3965 hydrochloride, >=98%;GW-3965 hydrochloride GW3965;GW 3965 HYDROCHLORIDE; GW-3965 HYDROCHLORIDE;;3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-di…;2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylet...;3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenylacetic Acid Hydrochloride
- CBNumber
- CB5972490
- Molecular Formula
- C33H31ClF3NO3.HCl
- Formula Weight
- 0
- MOL File
- 405911-17-3.mol
GW 3965 HYDROCHLORIDE Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- color
- white
- InChIKey
- NMPUWJFHNOUNQU-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- G6295
- Product name
- GW3965 hydrochloride
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $206
- Updated
- 2024/03/01
- Product number
- G6295
- Product name
- GW3965 hydrochloride
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $702
- Updated
- 2024/03/01
- Product number
- 10054
- Product name
- GW 3965 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $39
- Updated
- 2024/03/01
- Product number
- 10054
- Product name
- GW 3965 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 10054
- Product name
- GW 3965 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $175
- Updated
- 2024/03/01
GW 3965 HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
GW3965 Hydrochloride, is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.
Biochem/physiol Actions
GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.
storage
Desiccate at RT
GW 3965 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
GW 3965 HYDROCHLORIDE Suppliers
View Lastest Price from GW 3965 HYDROCHLORIDE manufacturers
- Product
- GW 3965 HYDROCHLORIDE 405911-17-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.8%
- Supply Ability
- 20tons
- Release date
- 2020-01-08